A one pot, three component synthesis of coumarin hybrid thiosemicarbazone derivatives and their antimicrobial evolution

Abstract

A convenient, one-pot, multi-component protocol for the preparation of 2-(1-(2-oxo-2Hchromen-3-yl)ethylidene)hydrazinecarbothioamide derivatives has been achieved. Here, firstly we have reported the synthesis of 3-acetyl-2H-chromen-2-one using starch sulfuric acid and cellulose sulfuric acid as biodegradable catalysts. Subsequently, we also carried out the reaction of isothiocynates, hydrazine hydrate and 3-acetyl-2H-chromen-2-one in the presence of catalytic amount of glacial acetic acid in refluxing ethanol to afford corresponding 2-(1-(2-oxo-2H-chromen-3-yl)ethyli dene)hydrazinecarbothioamide derivatives in high to excellent yields. All synthesized compounds were screened for antimicrobial activity. All compounds were found to show good to excellent activity against Escherichia coli MTCC 443.